Fig. 4
From: Surveillance and characterization of avian-origin H3N2 canine influenza viruses in 2021 in China
Histological lesions caused by H3N2 CIVs in the lungs of mice. Mice were euthanized on day 4 p.i. with 106 EID50 of test virus, and the lungs were collected for pathological study. Lungs of (A) Cn/BJ/362/09, B Cn/BJ/0124-300/15, G Cn/BJ/0501/21, and (H) Cn/BJ/0510/21 showed no significant histopathological changes (H&E staining). E Cn/GZ/1180/19 and F Cn/BJ/0118/21 virus-inoculated animal showed moderate histopathological changes (H&E staining), whereas the lungs of (C) Cn/BJ/1228-59/16 and D Cn/SH/159/17 virus-inoculated mice showed severe pathological lesions (H&E staining). I The lung samples of mice inoculated with PBS. Scale bar, 200 μm. J Microscopic lesions were counted