Mechanisms of probiotic Bacillus against enteric bacterial infections

Zhu, Jiajia; Chen, Yunsheng; Imre, Kálmán; Arslan-Acaroz, Damla; Istanbullugil, Fatih Ramazan; Fang, Yuwen; Ros, Gaspar; Zhu, Kui; Acaroz, Ulas

doi:10.1186/s44280-023-00020-0

One Health Advances

Table 3 Antimicrobial metabolites in probiotic Bacillus

From: Mechanisms of probiotic Bacillus against enteric bacterial infections

Classification	Compounds	Producer species^a	Type of BGCs^b	Spectrum^c	Targets^d	References
Compounds synthesized by ribosome and post-translationally modified
Lantibiotics	Amylolysin	B. amyloliquefaciens	RiPP	G⁺	Cell membrane, lipid II	[55]
	Cerecidins	B. cereus	Lanthipeptide	G⁺	Cell membrane	[56]
	Clausin	B. clausii	RiPP	G⁺	Cell wall	[57, 58]
	Coagulin	B. coagulans	RiPP-like	G⁺	-	[59]
	Entianin	B. subtilis	Lanthipeptide	G⁺	Cell wall, membrane	[60]
	Formicin	B. paralicheniformis	RiPP	G⁺	Cell membrane	[61]
	Haloduracin	B. halodurans	RiPP	G⁺	Cell wall, membrane	[62, 63]
	Lichenicidin	B. licheniformis	Lanthipeptide	G⁺	Cell membrane	[64, 65]
	Megacin	B. megaterium	RiPP	G⁺	Cell membrane	[66, 67]
	Mersacidin	Bacillus sp.	Lanthipeptide	G⁺	Cell wall, membrane	[68, 69]
	Pseudomycoicidin	B. pseudomycoides	RiPP	G⁺	-	[70]
	Plantazolicin A, B	B. velezensis	RiPP	G⁺	Cell membrane	[71]
	Sublancin 168	B. subtilis	Lanthipeptide	G⁺	PTS	[72]
	Sublichenin	B. licheniformis	RiPP	G⁺, G⁻	-	[73]
	Subtilin	B. subtilis	Lanthipeptide	G⁺	Cell wall	[74]
	Subtilomycin	B. subtilis	Lanthipeptide	G⁺, G⁻	-	[75]
	Subtilosin A	B. subtilis	Thiopeptide	G⁺	Cell membrane, Quorum sensing	[76, 77]
	Thuricins	B. thuringiensis	RiPP	G⁺	Cell membrane	[78, 79]
	Thurincin H	B. thuringiensis	RiPP	G⁺, G⁻	Cell membrane or cell wall	[80]
	Thiocillins	B. cereus	Thiopeptide	G⁺	Protein synthesis	[81]
Peptide compounds synthesized by non-ribosomal peptide synthetase
Cyclic Cationic Lipopeptides	Bacitracin	B. subtilis	NRPS	G⁺	Cell wall	[82]
	Circulin group:
	Circulin	B. circulans	NRPS	G⁺, G⁻, fungus	-	[83]
	Polypeptin A-B	B. circulans	NRPS	G⁺, G⁻	-	[84]
	Polymyxin analogues:
	Polymyxin A-E	B. polymyxa (namely Paenibacillus polymyxa)	NRPS	G⁺, G⁻	Cell membrane	[85]
	Octapeptin analogues:
	Octapeptin A-D	Bacillus sp. and Paenibacillus sp.	NRPS	G⁺, G⁻	Cell membrane	[86, 87]
Cyclic Noncationic Lipopeptides	Bacilotetrins A, B	B. subtilis	NRPS	G⁺	-	[88]
	Locillomycin	B. subtilis	PKS/NRPS	G⁺, virus	-	[89]
	Iturin analogues:
	Bacillomycin	B. velezensis	PKS/NRPS	Fungus, G⁺	Cell membrane	[90,91,92]
	Iturins	B. subtilis	PKS/NRPS	Fungus, G⁺	Cell membrane	[45, 93]
	Mycosubtilin	B. subtilis	PKS/NRPS	Fungus, G⁺	Cell membrane	[92, 94]
	Surfactin analogues:
	Bacaucin	B. subtilis	NRPS	G⁺	Cell membrane	[95]
	Lichenysins	B. licheniformis	NRPS	G⁺	Cell membrane, biofilm formation	[96, 97]
	Pumilacidin	B. pumilus	NRPS	G⁺, virus	-	[98, 99]
	Surfactins	B. subtilis	NRPS	Fungus, virus, G⁺	Cell membrane, quorum sensing, protein synthesis, cell metabolism	[100, 101]
	Fengycin analogues:
	Fengycins	B. subtilis	NRPS	Fungus, G⁺	Cell membrane, quorum sensing	[16, 102]
	Plipastatin	B. subtilis	NRPS	Fungus, G⁺	Cell membrane, wall	[31, 103]
	Fusaricidin analogues
	Fusaricidins	Paenibacillus sp.	PKS/NRPS	G⁺, Fungus	Cell membrane, cell metabolism	[104, 105]
Liner Cationic Lipopeptides	Bogorol A	Bacillus sp.	NRPS	G⁺	-	[106]
	Cerexin A-D	B. cereus	NRPS	G⁺	-	[107]
	Gageopeptides	B. subtilis	NRPS	G⁻, G⁺, fungus	-	[108]
	Gageostatins	B. subtilis	NRPS	G⁻, G⁺, fungus	-	[109]
	Gageotetrins	B. subtilis	NRPS	G⁻, G⁺, fungus	Cell membrane	[110]
	Tridecaptin A-C	B. polymyxa (namely Paenibacillus polymyxa)	NRPS	G⁻	lipid II	[111]
	Zwittermicin A	B. cereus	PKS/NRPS	Fungus, G⁺, G⁻	-	[112]
Liner Lipopeptides	Bacillin	B. subtilis	NRPS	G⁻, G⁺	Cell membrane	[113]
Liner Lipopeptides	Bacilysin	B. subtilis	Other	G⁻, G⁺, fungus	Cell wall, membrane	[114]
Polyketide compounds synthesized by polyketide synthetase or polyketide synthetase/non-ribosomal peptide synthetase
	Amicoumacin	B. pumilus	PKS/NRPS	G⁻, G⁺	Protein synthesis	[48, 115]
	Bacillaene	B. subtilis	PKS/NRPS	Fungus, G⁻, G⁺	Biofilm formation, Protein synthesis	[116, 117]
	Difficidin	B. velezensis	PKS/NRPS	Fungus, G⁺, G⁻	Cell wall, Protein synthesis	[114]
	Macrolactin	B. velezensis	PKS	G⁻, G⁺	Protein synthesis	[118, 119]

^a Antimicrobial metabolites listed in the table are commonly produced by producer species but not limited in these species
^b The type of BGCs is categorized according to the published researches and MIBiG database
^c Their activities are shown in the way of whether exhibit the inhibition of the growth of pathogenic bacteria (Gram-positive G⁺ and Gram-negative G⁻), fungus or virus
^d It represents unknown antibacterial targets. The abbreviations in the table can be found in the abbreviation list

Back to article page

ISSN: 2731-9970

Contact us

Submission enquiries: onehealthadv@cau.edu.cn
General enquiries: info@biomedcentral.com