Fig. 6

Structural explanations of the effect of critical mutations on Bi-Nab activity. A The epitopes for 32C7 and 35B5 on the surface of RBD are mapped. The epitopes for 32C7 and 35B5 (with black contours) on the RBD are colored blue and purple, respectively. The overlapping epitopes are mapped with red contours. B Mutations that have been reported in the RBD region of VBMs and VOCs are shown in Excel. C Mutations in the RBD of VBMs in (B) are indicated by red spheres on the surface representation of the S trimer. D Mutations in the RBD of VOCs indicated in (B) as red spheres on the S trimer structure, on which the epitopes of 32C7 (blue) and 35B5 (purple) are shown. The structure was visualized by PyMol (Schrodinger: https://www.schrodinger.com/pymol)