Fig. 4From: An RBD bispecific antibody effectively neutralizes a SARS-CoV-2 Omicron variantBroad neutralization of Bi-Nab against WT and VBM pseudoviruses. The neutralization breadth of Bi-Nab or parental antibodies was tested against a SARS-CoV-2 pseudovirus panel consisting of spikes of WT (A), Alpha (B), Beta (C), and Kappa (D) VBM strains. Heatmaps of IC50, breadth and potency are shown in (E), and warmer colors were used to indicate more potent neutralization. The neutralization breadth of an antibody against SARS-CoV-2 VBMs was based on the maximum percentage of pseudovirus that can be neutralized by that antibody. The IC50 values were determined by a nonlinear four-parameter dose‒response curve. Error bars represent the mean values ± SEMsBack to article page